Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus

摘要

Four new compounds were isolated from the Vietnamese marine sediment-derived fungus , one aspyrone-related polyketide aspilactonol G ( ), one meroterpenoid 12-epi-aspertetranone D ( ), two drimane derivatives ( , ), together with five known metabolites ( , , , , , ). The structures of compounds – were established by NMR and MS techniques. The absolute stereoconfigurations of compounds and were determined by a modified Mosher’s method. The absolute configurations of compounds and were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds and exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.