Relationship between right heart echocardiographic parameters and invasivepulmonary artery pressures in canine models of chronic embolic pulmonaryhypertension

摘要

Basic information related to the association between right heart echocardiographicparameters and invasive pulmonary artery pressure (PAP) in dogs with pulmonary hypetension(PH) is scarce. The aim of this study was to examine the association between conventionalright heart echocardiographic parameters and invasive PAP by right heart catheterization(RHC) before and after PH. Five female beagle dogs regarded as clinically healthy wereused. Echocardiography and RHC were conducted before and after creating chronic embolicpulmonary hypertension (CEPH) models. The acceleration time to ejection time ratio inpulmonary artery flow profile (AT/ET), the ratio of the pulmonary artery and aorticdiameter in diastole (PA/Ao), the right pulmonary artery distensibility index by M-modemethod (RPAD ), the normalized right ventricular internal diameter indiastole (RVIDdn), and the normalized tricuspid annular plane systolic excursion (TAPSEn)were correlated with the invasive systolic PAP (sPAP), mean PAP (mPAP) and diastolic PAP(dPAP). Multiple linear regression analysis identified AT/ET and RVIDdn as independentpredictors of sPAP, PA/Ao and RVIDdn as independent predictors of mPAP, and PA/Ao and RPAD as independent predictors of dPAP. AT/ET and PA/Ao had highsensitivity and specificity for predicting CEPH. In conclusion, AT/ET, PA/Ao, RPAD , RVIDdn and TAPSEn were significantly correlated with invasive PAP andalterations in PA/Ao or AT/ET might enable clinicians to predict PH, even if tricuspidregurgitation is not observed.