Characterization of IL-19 -20 and -24 in acute and chronic kidney diseases reveals a pro-fibrotic role of IL-24

摘要

Renal expression of , , and their receptors following unilateral ureteral obstruction (UUO). Renal mRNA expression of ( ), ( ), ( ), ( ) ( ) and ( ) of mice underwent UUO and that of controls was determined by real-time RT-PCR in comparison with as internal control. The renal protein amount of IL-20RB of WT mice underwent UUO and that of controls was measured by Western blot analysis in comparison with GAPDH as internal control ( and Additional file : Figure S4a). Localization of IL-20RB (brown; ) was investigated by immunohistochemical staining in the kidney of mice underwent UUO and in that of controls. Values were expressed as mean ± SD.  = 5–6 in each group; *p h)