Cerium oxide nanoparticles improve liver regeneration after acetaminophen-induced liver injury and partial hepatectomy in rats

摘要

Characterization of cerium oxide nanoparticles. , Representative TEM images of CeO NPs at different magnifications showing the non-aggregate and spherical shape of the engineered nanoparticles. Inset in is a High Resolution TEM image of single particle showing pure CeO atomic planes; UV–Visible absorption spectrum of the as-synthesized CeO NPs; XRD spectrum of the as-synthesized CeO NPs after being dried under vacuum. Z-Potential distribution and Hydrodynamic diameter measured by DLS of the CeO NPs dispersed in the physiological media (saline solution at pH = 5.5); Cerium concentration in liver, spleen, lung and and kidney from rats treated with CeO NPs for 90 min, 3, 6 and 8 weeks (n = 4 for each group). Oxidative stress was quantified in non-treated and CeO NPs-treated HepG2 cells by measuring DCF fluorescence in basal condition and after inducing oxidative stress with 2 mM H O added to the culture medium ( vs basal and