CD244 represents a new therapeutic target in head and neck squamous cell carcinoma

摘要

Developing novel strategies to overcome the immunosuppressive tumor microenvironment is a critically important area of cancer therapy research. Here, we assess the therapeutic potential of CD244 (2B4/signaling lymphocyte activation molecule family 4), an immunoregulatory receptor found on a variety of immune cells, including exhausted CD8 T cells, dendritic cells (DCs), and myeloid-derived suppressor cells (MDSCs).