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A Case of Logopenic Variant of Primary Progressive Aphasia with Parkinsonism and Anosmia

机译:原发性进行性失语症对症开放变异伴帕金森氏症和失语症一例

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摘要

A 69-year-old right-handed woman developed difficulty naming objects and word-finding. The clinical features of language disorder and predominant atrophy on MRI and predominant hypoperfusion on I-IMP SPECT in the left temporo-parietal junction area were consistent with the diagnostic criteria for the logopenic variant of primary progressive aphasia (lvPPA). Neurological examination showed slight right-side rigidity and resting tremor (UPDRS-III: 4). I-FP-CIT SPECT showed presynaptic dopamine transporter reduction in the posterior putamina with left-side predominance. The odor-stick identification test for Japanese exhibited complete loss of the sense of smell (anosmia). These findings suggest that lvPPA may be accompanied by parkinsonism and anosmia.
机译:一名69岁的惯用右手的女人在命名物体和寻找单词时遇到困难。左颞顶顶交界区的语言障碍和MRI上的主要萎缩以及I-IMP SPECT上的主要灌注不足的临床特征与原发性渐进性失语症(lvPPA)的低位变异的诊断标准一致。神经系统检查显示轻微的右侧僵硬和静息性震颤(UPDRS-III:4)。 I-FP-CIT SPECT显示左侧后突肌中突触前多巴胺转运蛋白减少。日本人的气味棒识别测试显示完全失去了嗅觉(失眠)。这些发现表明lvPPA可能伴有帕金森氏症和失眠症。

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