Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy

机译：pH响应前药胶束共同递送紫杉醇和阿霉素用于癌症治疗

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摘要

It is of great significance to develop intelligent co-delivery systems for cancer chemotherapy with improved therapeutic efficacy and few side-effects.

机译：开发具有改善的治疗效果且几乎没有副作用的用于癌症化疗的智能共同递送系统具有重要意义。

著录项

期刊名称 International Journal of Nanomedicine
作者
Yanhua Jiang; Yongjian Zhou; Can Yang Zhang; Te Fang;
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作者单位

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年(卷),期 2020(15),-1
年度 2020
页码 -1
总页数 13
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
pH-responsive; polyprodrug micelles; co-delivery; controlled release; cancer therapy;

机译：pH响应;多前药胶束;共同递送;控释;癌症治疗;

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外文文献
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专利

1. Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy [J] . Yanhua Jiang, Yongjian Zhou, Can Yang Zhang, International Journal of Nanomedicine . 2020,第1期

机译：紫杉醇和多柔比蛋白的共同递送pH响应前药胶束进行癌症治疗
2. pH-sensitive polymeric micelles formed by doxorubicin conjugated prodrugs for co-delivery of doxorubicin and paclitaxel [J] . Ma Yakun, Fan Xiaohui, Li Lingbing Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides . 2016,第Null期

机译：由阿霉素共轭前药形成的pH敏感的聚合物胶束，用于阿霉素和紫杉醇的共输送
3. Co-Delivery of Paclitaxel by a Capsaicin Prodrug Micelle Facilitating for Combination Therapy on Breast Cancer [J] . Lan Yang, Sun Yue, Yang Tong, Molecular pharmaceutics . 2019,第8期

机译：通过辣椒素前药胶束共同递送紫杉醇，促进乳腺癌联合治疗
4. POLY (ETHYLENE OXIDE)-POLY(ε-CAPROLACTONE) MICELLES IN DIFFERENT MORPHOLOGIES: ADVANTAGES OF WORM-LIKE MICELLES FOR DELIVERY OF PACLITAXEL IN LUNG CANCER THERAPY [C] . Shenshen Cai, Tamara Minko, Dennis E. Discher Controlled Release Society Annual Meeting and Exposition . 2007

机译：不同形态的聚（环氧乙烷）-聚（ε-己内酯）胶束：蠕虫状胶束在肺癌治疗中递送帕西他赛的优势
5. Delivery of paclitaxel via pH-responsive polymeric nanoparticles for prevention of lung cancer and mesothelioma recurrence. [D] . Griset, Aaron Paul. 2010

机译：通过pH响应性聚合物纳米颗粒递送紫杉醇可预防肺癌和间皮瘤复发。
6. Smart Polymeric Nanoparticles with pH-Responsive and PEG-Detachable Properties (II): Co-Delivery of Paclitaxel and VEGF siRNA for Synergistic Breast Cancer Therapy in Mice [O] . Mingji Jin, Yan Hou, Xiuquan Quan, 2021

机译：具有pH响应和PEG可拆卸性质（II）的智能聚合物纳米颗粒：共同递送紫杉醇和VEGF siRNA用于小鼠的协同乳腺癌治疗
7. pH and redox dual-responsive copolymer micelles with surface charge reversal for co-delivery of all-trans-retinoic acid and paclitaxel for cancer combination chemotherapy [O] . Yanqiu Zhang, Lianjun Peng, Jiahui Chu, 2018

机译：具有表面电荷反转的pH和氧化还原双响应共聚物胶束，用于共同递送所有 - Trans - 癌症组合化疗的 - 丙酸和紫杉醇

8. Synergistic Cytotoxicity of Human Breast Cancer Cells by a Novel Nano- Particle Based Delivery of Ceramide With Paclitaxel and/or Doxorubicin [R] . Mehta, S. 2004

机译：基于纳米粒子的神经酰胺与紫杉醇和/或多柔比星递送的人乳腺癌细胞的协同细胞毒性

1. 阿霉素+环磷酰胺序贯紫杉醇和阿霉素+紫杉醇序贯每周紫杉醇在高风险乳腺癌患者辅助化疗中的多中心Ⅲ期随机对照研究 [J] . 王坤 . 循证医学 . 2007,第3期

2. pH响应性聚合物胶束在药物递送系统中的研究进展 [J] . 李艳艳 ,毕韵梅 . 化工管理 . 2020,第028期

3. 阿霉素前药纳米粒/姜黄素联合递送系统的构建及其抗肿瘤研究 [J] . 褚丽萍 ,刘金剑 ,杨翠红 . 中国生化药物杂志 . 2016,第001期

4. pH响应性聚合物胶束的制备、表征及对阿霉素的控制释放研究 [J] . 苑莹芝 ,马敏 ,张丹 . 化学研究 . 2016,第005期

5. 紫杉醇和多西紫杉醇双药胶束体外稳定性考察 [J] . 邵铖祎 ,郦江平 ,涂家生 . 中国药科大学学报 . 2010,第5期

6. 阿霉素和紫杉醇联合给药胶束用于耐药肿瘤的研究 [C] . 陈彦佐 ,陈欣怡 ,范卓洋 . 2012年中国药学大会暨第十二届中国药师周 . 2012

7. 基于聚多肽-阿魏酸/硫辛酸衍生物的多功能集成胶束用于阿霉素的高效递送 [A] . 陈涛 . 2018

1. 酸敏感型紫杉醇前药、其制备方法及前药纳米胶束 [P] . 中国专利： CN107353399B . 2019.03.19

2. 酸敏感型紫杉醇前药、其制备方法及前药纳米胶束 [P] . 中国专利： CN107353399A . 2017-11-17

3. method for determining if ec145 is indicated for the treatment of a patient with an ovarian tumor or a lung tumor; method for predicting a response from an ovarian tumor or a lung tumor of a patient to ec145 therapy; method of treating platinum-resistant ovarian cancer in a patient in need; use of ec145 in combination with pegylated liposomal doxorubicin; use of ec145 for the manufacture of a medicament; method for obtaining a clinical benefit compared to treatment with a therapeutic amount of pegylated liposomal doxorubicin in the treatment of platinum-resistant ovarian cancer in a patient in need thereof; method for selecting a patient for treatment; pharmaceutical composition; dosage unit, method for determining if a patient with a tumor has functionally active folate receptors present in the patient's tumor; method of treating a folate receptor expressing epithelial tumor in a patient in need thereof; and; method for obtaining a clinical benefit in the treatment of a folate recepto [P] . 外国专利： BR112012002064A2 . 2017-05-09

机译：确定ec145是否适合治疗卵巢肿瘤或肺肿瘤患者的方法;预测患者的卵巢肿瘤或肺肿瘤对ec145治疗的反应的方法;在有需要的患者中治疗铂耐药的卵巢癌的方法; ec145与聚乙二醇化阿霉素组合使用; ec145在制造药物中的用途;与治疗量的聚乙二醇化脂质体阿霉素治疗相比获得临床益处的方法，在有需要的患者中治疗铂耐药性卵巢癌;选择患者进行治疗的方法;药物组合物;剂量单位，用于确定患有肿瘤的患者是否具有存在于患者肿瘤中的功能活性叶酸受体的方法;在有需要的患者中治疗表达叶酸受体的上皮肿瘤的方法;和;治疗叶酸受体的临床方法

4. Water soluble paclitaxel prodrugs formed by conjugating paclitaxel or docetaxel with a polyglutamic acid polymer and use for treating cancer [P] . 外国专利： NZ332234A . 2000-06-23

机译：通过将紫杉醇或多西紫杉醇与聚谷氨酸聚合物结合形成的水溶性紫杉醇前药，并用于治疗癌症

5. Method for obtaining conjugate of paclitaxel, trastuzumab and dendrimer PAMAM of 4th generation that has 64 amino groups on its surface and application of paclitaxel, trastuzumab and dendrimer PAMAM of 4th generation that has 64 amino groups on its surface for production of a drug intended for therapy of breast cancer [P] . 外国专利： PL421440A1 . 2018-11-05

机译：获得表面具有64个氨基的第四代紫杉醇，曲妥珠单抗和树枝状聚合物PAMAM的结合物的方法和表面具有64个氨基的第四代紫杉醇，曲妥珠单抗和树枝状聚合物PAMAM的应用以生产用于治疗的药物乳腺癌

相关主题

Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy

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