The columns show a representative example eye for each drusen type (from left to right) with color fundus photography (first row), fundus autofluorescence imaging (second row), and the horizontal spectral-domain optical coherence tomography B-scan centered to the fovea (third row). The overlay in the color fundus photographs displays the results of the first dark-adapted cyan test. The last row depicts the corresponding cumulative defect (Bebie) curves for each type of testing. The normative data with 95% confidence intervals are shown in the background. The data of the patient are plotted in the foreground. Patient 6 (P6) exhibited multiple, yellowish, small, round, “hard” drusen with distinct borders and was classified as predominant cuticular drusen. The cumulative defect curves indicated that the mesopic and dark-adapted red deficit exceeded the dark-adapted cyan deficit. Patient 24 (P24) exhibited multiple confluent “soft” drusen and was thus classified as predominant soft drusen. The cumulative defect curves indicated defect for all three types of testing. Patient 13 (P13) exhibited small dot- and ribbon-shaped lesion and was classified as predominant reticular drusen. The cumulative defect curves exhibited parallel shift for mesopic and dark-adapted red testing along the -axis (indicating global defect or media opacity) and most prominently global and diffuse defect for dark-adapted cyan testing
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