Soyasaponin A1 Inhibits the Lipid Raft Recruitment and Dimerization of TLR4 MyD88 and TRIF in Palmitate-Stimulated Inflammatory Macrophages

摘要

Soyasaponin A (SS ) was previously shown to inhibit the palmitate (PA)-induced inflammation via regulating the toll-like receptor 4 (TLR4) signaling in macrophages. Since the lipid raft recruitment and dimerization of TLR4 and its downstream adaptor molecules are vital for PA-initiated TLR4 signaling, we explored whether this process would be modulated by SS .