Influence of pharmacological and epigenetic factors to suppress neurotrophic factors and enhance neural plasticity in stress and mood disorders

摘要

Induced stress factors deregulate the structural remodelling of brain considering synaptic modifiers such as neurotropins and glucocorticoids disrupt the cognitive ability and decreases the DLPFC and VmPFC region functioning ( ). Neural plasticity occurs, due to dysregulation in the pre- and post-synaptic neural receptor modelling, due to oxidative stress: in which unwanted oxidation of ions causes malfunctioning of transcription process resulting in genetic variation. Due to pharmacological and environmental factors:several drugs-abuses (like cocaine) affects synaptic NAc MSN excitability, resulting in the development and expression of addictive plasticity as receptors becomes familiar to these external agents and overgeneralize them as self or natural pathway mediator