Osteopontin Levels in Patients With Chronic Kidney Disease Stage 5 onHemodialysis Directly Correlate With Intact Parathyroid Hormone and AlkalinePhosphatase

摘要

Chronic kidney disease stage 5 (CKD5) marks the fifth stage of renal failure,frequently causing dysregulation of bone and mineral metabolism. Challengesexist in evaluating and managing chronic kidney disease–mineral bone disorder(CKD-MBD) with the standard panel of biomarkers. Our objective was to profileosteopontin (OPN) in patients with CKD5 on maintenance hemodialysis (CKD5-HD)and elucidate its relationship to phosphorus (P), calcium (Ca ),alkaline phosphatase (AP), and intact parathyroid hormone (iPTH) to improveunderstanding of the present model of CKD-MBD. Elevation of plasma OPN was seenin the CKD5-HD cohort (n = 92; median: 240.25 ng/mL, interquartile range [IQR]:169.85 ng/mL) compared to a normal group (n = 49; median: 63.30 ng/mL, IQR:19.20 ng/mL; < .0001). Spearman correlation tests revealedsignificant positive correlations of OPN with iPTH ( <.0001; = 0.561, 95% confidence interval = 0.397-0.690) andOPN with AP ( < .0001; = 0.444, 95%confidence interval = 0.245-0.590) in CKD5-HD patients. Ultimately, OPN may playan integral role in the MBD axis, suggesting that it may be important toactively monitor OPN when managing CKD5-HD.