Analysis of Flagellin-Specific Adaptive Immunity Reveals Links to Dysbiosis in Patients With Inflammatory Bowel Disease

摘要

Bacterial flagellin is an important antigen in inflammatory bowel disease, but the role of flagellin-specific CD4 T cells in disease pathogenesis remains unclear. Also unknown is how changes in intestinal microbiome intersect with those in microbiota-specific CD4 T cells. We aimed to quantify and characterize flagellin-specific CD4 T cells in Crohn’s disease (CD) and ulcerative colitis (UC) patients and study their relationship with intestinal microbiome diversity.