Protocol: Actions of annatto-extracted tocotrienol supplementation on obese postmenopausal women: study protocol for a double-blinded placebo-controlled randomised trial

摘要

Obesity is a major health concern in postmenopausal women, and chronic low-grade inflammation contributes to the development of obesity. Cellular studies and high-fat-diet-induced obese mouse model mimicking obesity show the antiobesity effect of annatto-extracted tocotrienols (TT) with antioxidant capability. We aim to assess the safety and efficacy of TT consumption for lipid-related parameters in obese postmenopausal women.