Transcription factor regulatory modules provide the molecular mechanisms for functional redundancy observed among transcription factors in yeast

摘要

Cells usually respond to environmental and physiological stress by reorganizing their DNA transcription programs, leading to correct spatial and temporal expression of different genes [ – ]. To subtly control the DNA transcription programs, transcription factors (TFs) coordinately bind to the promoter regions of their target genes and regulate the expression of these genes [ ]. The precise regulation of the binding of TFs depends on the interaction of different TFs, regulatory proteins and the epigenetic materials such as nucleosome and histone modifications [ – ]. Hence understanding the roles and mechanisms of TFs in transcriptional regulation is an important task and remains the on-going research in systems biology and molecular biology.