Consequences of CXCL10 and IL-6 Induction by the Murine IFN-α1 Transgene in Ocular Herpes Simplex Virus Type 1 Infection

摘要

Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a “latent” infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of type I interferon transgenes has been found to antagonize viral replication and spread from the eye to the nervous system. Associated with the in situ transfection of the cornea is the up-regulation of two inflammatory molecules, IL-6 and CXCL10. In this report, we will further examine the contribution these molecules may have in the host response to ocular infection with herpes simplex virus type 1.