HEMATOPOIETIC PROGENITOR CELLS (HPC) FROM MOBILIZED PERIPHERAL BLOOD DISPLAY ENHANCED MIGRATION AND MARROW HOMING COMPARED TO STEADY-STATE BONE MARROW HPC

摘要

ObjectiveFaster engraftment of G-CSF mobilized peripheral blood (MPB) transplants compared to steady-state bone marrow (ssBM) is well documented and clinically relevant. A number of different factors likely contribute to this outcome. In the present study we explored whether independent of cell number there are intrinsic differences in the efficiency of progenitor cell homing to marrow between MPB and ssBM.