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Enhanced response of human head and neck cancer xenograft tumors to Cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging

机译：人头颈部癌异种移植肿瘤对顺铂与2-脱氧-D-葡萄糖结合的反应增强与PET成像确定的18F-FDG摄取增加有关

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PurposeDetermine if the response of human head and neck cancer xenografts to cisplatin (CIS) could be enhanced with 2-deoxyglucose (2DG) and determine if 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG) uptake correlated with responses to this drug combination. Determine if 2DG would enhance CIS-induced radiosensitization.

机译：目的确定2-脱氧葡萄糖（2DG）是否能增强人头颈部癌异种移植物对顺铂（CIS）的反应，并确定是否吸收2- [F-18]-氟-2-脱氧-D-葡萄糖（FDG）与对该药物组合的反应相关。确定2DG是否会增强CIS诱导的放射增敏作用。

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期刊名称 other
作者
Andrean L. Simons; Melissa A. Fath; David M. Mattson; Brian J. Smith; Susan A. Walsh; Michael M. Graham; Richard D. Hichwa; John M. Buatti; Ken Dornfeld; Douglas R. Spitz;
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年(卷),期 -1(69),4
年度 -1
页码 1222–1230
总页数 16
原文格式 PDF
正文语种
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关键词
cisplatin 2-deoxyglucose HNSCC FDG-PET oxidative stress radiation;

机译：顺铂;2-脱氧葡萄糖;HNSCC;FDG-PET;氧化应激;辐射;

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1. Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging. [J] . Simons AL, Fath MA, Mattson DM, International Journal of Radiation Oncology, Biology, Physics . 2007,第4期

机译：人类头颈部癌异种移植肿瘤对顺铂与2-脱氧-D-葡萄糖结合的反应增强，与PET成像确定的18F-FDG摄取增加有关。
2. Tumor uptake and tumor/blood ratios for [Zr-89]Zr-DFO-trastuzumab-DM1 on microPET/CT images in NOD/SCID mice with human breast cancer xenografts are directly correlated with HER2 expression and response to trastuzumab-DM1 [J] . Al-saden Noor, Cai Zhongli, Reilly Raymond M. Nuclear Medicine and Biology . 2018,第期

机译：肿瘤摄取和肿瘤/血液比率为[ZR-89] ZR-DFO-TRASTUZUMAB-DM1在NOD / SCID小鼠中，具有人乳腺癌异种移植物的MICROPET / CT图像与HER2表达直接相关，并对TRASTUZUMAB-DM1的反应相关
3. Dynamic Contrast-Enhanced MRI Evaluates the Early Response of Human Head and Neck Tumor Xenografts Following Anti-EMMPRIN Therapy With Cisplatin or Irradiation [J] . Kim Hyunki, Hartman Yolanda E., Zhai Guihua, Journal of magnetic resonance imaging: JMRI . 2015,第4期

机译：动态对比增强MRI评估顺铂或辐射抗EMMPRIN治疗后人头颈部肿瘤异种移植的早期反应
4. Tumor Segmentation in Patients with Head and Neck Cancers Using Deep Learning Based-on Multi-modality PET/CT Images [C] . Mohamed A. Naser, Lisanne V. van Dijk, Renjie He, Challenge Conference on 3D Head and Neck Tumor Segmentation in PET/CT Challenge;International Conference on Medical Image Computing and Computer Assisted Intervention . 2020

机译：基于多种式宠物/ CT图像的深度学习患者肿瘤细分
5. Non-invasive in vivo assessment of tumor hypoxia using functional magnetic resonance (fMR) imaging during therapy in human head and neck squamous cell carcinoma (HNSCC) xenografts: Implications for assessing therapeutic efficacy. [D] . Bhattacharya, Arup. 2005

机译：在人头颈部鳞状细胞癌（HNSCC）异种移植物治疗期间，使用功能性磁共振（fMR）成像对肿瘤缺氧进行非侵入性体内评估：评估治疗功效的意义。
6. Dynamic Contrast Enhanced Magnetic Resonance Imaging Evaluates the Early Response of Human Head and Neck Tumor Xenografts following Anti-EMMPRIN therapy with Cisplatin or Irradiation [O] . Hyunki Kim, Yolanda E. Hartman, Guihua Zhai, -1

机译：动态对比增强磁共振成像评估使用顺铂或辐射抗EMMPRIN治疗后人头颈部肿瘤异种移植的早期反应
7. 2-Deoxy-d-Glucose Combined with Cisplatin Enhances Cytotoxicity via Metabolic Oxidative Stress in Human Head and Neck Cancer Cells [O] . Andrean L. Simons, Iman M. Ahmad, David M. Mattson, 2007

机译：2-脱氧-D-葡萄糖联合顺铂，通过人体头部和颈部癌细胞中的代谢氧化应激增强细胞毒性

Enhanced response of human head and neck cancer xenograft tumors to Cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging

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