High circulating levels of RBP4 and mRNA levels of aP2 PGC-1α and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects

摘要

Hammarstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U. (The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden; University of Kuopio and Kuopio University Hospital, Kuopio, Finland; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA). High circulating levels of RBP4 and mRNA levels of aP2, PGC-1α and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects.ContextHigh levels of circulating retinol-binding protein 4 (RBP4) and baseline expression of adipogenic genes correlate with subsequent improvement in insulin sensitivity following Thiazolidinedione (TZD) treatment.