The catalytic asymmetric addition of alkyl- and aryl-zinc reagents to an isoxazole aldehyde

摘要

Nucleophilic addition of alkyl- and aryl zinc reagents to a C(4) functionalized isoxazolyl aldehyde proceeded effectively with high enantioselectivity (85–94% e.e.). The amino alcohol catalyst (S)-2-piperidinyl-1,1,2-triphenyl ethanol (>10) afforded the (R)-product >2b, as established by x-ray crystallography.