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Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure Based Drug Design of Serine/Threonine Phosphatase Inhibitors

机译：绑定到Nodularin-R和互变霉素的蛋白磷酸酶1的晶体结构：基于丝氨酸/苏氨酸磷酸酶抑制剂的基于结构药物设计的新型支架。

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期刊名称 other
作者
Matthew S. Kelker; Rebecca Page; Wolfgang Peti;
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作者单位

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年(卷),期 -1(385),1
年度 -1
页码 11–21
总页数 18
原文格式 PDF
正文语种
中图分类
关键词
Protein phosphatase 1 nodularin-R tautomycin crystal structure molecular toxins;

机译：蛋白磷酸酶1;结节霉素-R;互变霉素;晶体结构;分子毒素;

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专利

1. Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors. [J] . Kelker MS, Page R, Peti W Journal of Molecular Biology . 2009,第1期

机译：蛋白质磷酸酶-1的晶体结构与结节霉素-R和互变霉素结合：一种新型的基于丝氨酸/苏氨酸磷酸酶抑制剂的基于结构药物设计的支架。
2. Design and preparation of serine–threonine protein phosphatase inhibitors based upon the nodularin and microcystin toxin structures. Part 3 [J] . Kerri L. Webster Antony B. Maude Michael E. ODonnell Amit P. Mehrotra and David Gani Journal of the Chemical Society, Perkin Transactions 1 . 2001,第14期

机译：基于结节蛋白和微囊藻毒素的结构设计和制备丝氨酸-苏氨酸蛋白磷酸酶抑制剂。第三部分
3. Design and preparation of serine-threonine protein phosphatase inhibitors based upon the nodularin and microcystin toxin structures. Part 30 [J] . Kerri L. Webster, Antony B. Maude, Michael E. ODonnell, Journal of the Chemical Society, Perkin Transactions 1 . 2001,第14期

机译：基于结节蛋白和微囊藻毒素的结构设计和制备丝氨酸-苏氨酸蛋白磷酸酶抑制剂。第30章
4. Inhibition of Serine-Threonine Protein Phosphatases in Monocyte Chemoattractant Protein-1 Expression in Helicobacter pylori-Stimulated Gastric Epithelial Cells [C] . HAE-YUN CHUNG, BORAM CHA, HYEYOUNG KIM Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：幽门螺杆菌刺激的胃上皮细胞单核细胞趋化蛋白-1表达中丝氨酸-苏氨酸蛋白磷酸酶的抑制。
5. A rational approach to protein phosphatase-1 selective inhibitors: Synthesis of the cyclic hepatotoxin microcystin-LA, design and synthesis of analogs of microcystin-LA, and synthesis of truncated analogs of microcystin-LA [D] . Aggen, James Bradley 1998

机译：一种合理的蛋白磷酸酶-1选择性抑制剂方法：环状肝毒素微囊藻毒素-LA的合成，微囊藻毒素-LA的类似物的设计和合成以及微囊藻毒素-LA的截短类似物的合成
6. High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design [O] . George T. Lountos, Sreejith Raran-Kurussi, Bryan M. Zhao, -1

机译：酪氨酸磷酸酶epsilon D1和D2域的高分辨率晶体结构用于基于结构的药物设计
7. Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors [O] . Matthew S. Kelker, Rebecca Page, Wolfgang Peti 2009

机译：蛋白质磷酸酶-1的晶体结构结合Nodularin-R和幼灰霉素：一种用于丝氨酸/苏氨酸磷酸酶抑制剂的基于结构的药物设计的新型支架
8. Crystallization, X-Ray Structure Determination and Structure-Based Drug Design for Targeted Malarial Enzymes [R] . Chattopadhyay, D. 2000

机译：针对靶向疟疾酶的结晶，X射线结构测定和基于结构的药物设计

Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure Based Drug Design of Serine/Threonine Phosphatase Inhibitors

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