METHOD FOR MODULATING FUNCTION OF SERINE(THREONINE)PROTEIN KINASE WITH AZABENZIMIDAZOLE-BASE COMPOUND, METHOD FOR IDENTIFYING COMPOUNDS MODULATING FUNCTION OF SERINE(THREONINE)PROTEIN KINASE, METHOD FOR PROPHYLAXIS OR TREATMENT OF PATHOLOGICAL STATE IN BODY, AZABENZIMIDAZOLE-BASE COMPOUND, METHOD FOR ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry, medicine, biochemistry, pharmacy.;SUBSTANCE: invention relates to new derivatives of azabenzimidazole of formulas I, II, or III given in the invention description that modulate function of serine(threonine)protein kinase, methods for modulating function of serine(threonine)protein kinase, method for identifying compounds modulating function of serine(threonine)protein kinase, to method for treatment of pathological states associated with serine(threonine)protein kinase using indicated compounds, method for synthesis of indicated compounds based on formulas (I), (II) or (III). Proposed compounds provides the effective modulating the function of serine(threonine)protein kinase and reduce amount of adverse effects in treatment of the corresponding diseases.;EFFECT: improved modulating method, valuable medicinal and biochemical properties of compounds.;32 cl, 5 tbl, 7 ex