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The AT1 receptor antagonist L-158809 prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment

机译：AT1受体拮抗剂L-158809可预防或改善全脑辐射诱发的认知功能障碍

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摘要

PurposeWe hypothesized that administration of the angiotensin type 1 (AT1) receptor antagonist, L-158,809, to young adult male rats would prevent or ameliorate fractionated whole-brain irradiation (WBI)-induced cognitive impairment.

机译：目的我们假设向年轻成年雄性大鼠施用1型血管紧张素（AT1）受体拮抗剂L-158,809可以预防或改善全脑辐射（WBI）引起的认知损害。

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期刊名称 other
作者
Mike E. Robbins; Valerie Payne; Ellen Tommasi; Debra I Diz; Fang-Chi Hsu; William R. Brown; Kenneth T. Wheeler; John Olson; Weiling Zhao;
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作者单位

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年(卷),期 -1(73),2
年度 -1
页码 499–505
总页数 16
原文格式 PDF
正文语种
中图分类
关键词
rat brain fractionated whole-brain irradiation cognitive impairment renin-angiotensin system L-158809 AT1 receptor antagonists;

机译：大鼠脑;全脑分级照射;认知障碍;肾素-血管紧张素系统;L-158809;AT1受体拮抗剂;

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专利

1. The AT1 receptor antagonist, L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. [J] . Robbins ME, Payne V, Tommasi E, International Journal of Radiation Oncology, Biology, Physics . 2009,第2期

机译：AT1受体拮抗剂L-158,809可以预防或改善全脑辐射诱发的认知功能障碍。
2. Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment [J] . Lee T.C., Greene-Schloesser D., Payne V., Radiation Research: Official Organ of the Radiation Research Society . 2012,第1期

机译：长期服用血管紧张素转换酶抑制剂雷米普利可预防全脑照射引起的诱导的周围皮层皮质依赖性认知功能障碍
3. Targeting colony stimulating factor 1 receptor to prevent cognitive deficits induced by fractionated whole-brain irradiation [J] . Xi Feng, Susanna Rosi Ph.D. Neural regeneration research . 2017,第3期

机译：靶向菌落刺激因子1受体，以防止通过分级全脑照射引起的认知缺陷
4. A Study of Evaluation of Vision Training System to Prevent Mild Cognitive Impairment [C] . Fumiya Kinoshita, Rentaro Ono, Keita Ichikawa, International Conference on Computer Science and Education . 2020

机译：预防轻度认知障碍的视觉训练系统评估研究
5. Experimental cerebral malaria induces cerebral vascular dysfunction and cognitive impairment via endothelin a receptor signaling [D] . Freeman, Brandi Danielle. 2015

机译：实验性脑疟疾通过内皮素A受体信号传导诱导脑血管功能障碍和认知障碍
6. Effects of the AT1 Receptor Antagonist L-158809 on Microglia and Neurogenesis after Fractionated Whole-Brain Irradiation [O] . Kelly R. Conner, Valerie S. Payne, M. Elizabeth Forbes, -1

机译：在aT1受体拮抗剂L-158809的小胶质细胞和神经发生分馏全脑照射后的影响。
7. The AT1 Receptor Antagonist, L-158,809, Prevents or Ameliorates Fractionated Whole-Brain Irradiation–Induced Cognitive Impairment [O] . Mike E. Robbins, Valerie Payne, Ellen Tommasi, 2009

机译：AT1受体拮抗剂，L-158,809，可防止或改善分级的全脑照射引起的认知障碍
8. Is All Radiation-Induced Emesis Ameliorated by 5-HT3 Receptor Antagonists [R] . Rabin, B. M., King, G. L. 1992

机译：5-HT3受体拮抗剂改善了所有辐射诱导的呕吐

The AT1 receptor antagonist L-158809 prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment

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