Construction of 56-Ring Fused 2-Pyridones: An Effective Annulation Tactic Achieved in Water

摘要

An efficient protocol for elaboration of the 5,6-fused 2-pyridone ring system, exploiting the tandem condensation of propiolamide and cyclic β-ketomethyl esters in water, followed by acid or base promoted intramolecular ring closure and decarboxylation, has been developed.