Synergistic efficacy of combination of Enfuvirtide and Sifuvirtide the first and next generation HIV fusion inhibitors

摘要

Enfuvirtide and Sifuvirtide, the first and next generation HIV fusion inhibitors, contain different functional domains and have distinct target sites. Here we found that combination of Enfuvirtide and Sifuvirtide resulted in potent synergism in inhibiting HIV-1-mediated cell-cell fusion and infection by X4 and R5 as well as Enfuvirtide-resistant HIV-1 strains. These findings suggest that application of Enfuvirtide and Sifuvirtide in combination may improve their efficacy and resistant profile, leading to reduction of the dosage and frequency of drug use.