Sifuvirtide Screens Rigid Membrane Surfaces. Establishment of a Correlation between Efficacy and Membrane Domain Selectivity among HIV Fusion Inhibitor Peptides

摘要

Sifuvirtide, a 36 amino acid negatively charged peptide, is a novel and promising HIV fusion inhibitor, presently in clinical trials. Because of the aromatic amino acid residues of the peptide, its behavior in aqueous solution and the interaction with lip