A persulfated molecular umbrella derived from one spermine, four lysine and eight deoxycholic acid molecules was found to exhibit ionophoric activity, as shown by pH discharge, and Na+ and Cl− transport experiments. In sharp contrast, a moderately more hydrophilic analog derived from cholic acid showed no such ionophoric activity. Both molecular umbrellas crossed liposomal membranes by passive transport with experimental rates that were similar. These findings show how the interactions between such amphomorphic molecules and phospholipid bilayers are a sensitive function of the umbrella’s hydrophilic/lipophilic balance (HLB). They also raise the possibility of exploiting molecular umbrellas in fundamentally new ways.
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