Reduced lung cancer mortality and exposure to synthetic fluids and biocide in the auto manufacturing industry

摘要

ObjectivesWater-based soluble and synthetic metalworking fluids (MWF) used in auto manufacturing may be contaminated by endotoxin from Gram-negative bacteria, a possible anticarcinogen via increased immuno-surveillance. The effectiveness of biocide, generally added to limit bacterial growth is unknown. We investigated whether an inverse relationship between lung cancer and synthetic MWF and biocide – as surrogates of endotoxin exposure – persisted in an extended follow-up of autoworkers.