Camphoratins A–J Potent Cytotoxic and Anti-inflammatory Triterpenoids from the Fruiting Body of Taiwanofungus camphoratus

摘要

Ten new triterpenoids, camphoratins A–J (>1–>10), along with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis and chemical methods. Compound >10 is the first example of a naturally occurring ergosteroid with an unusual cis-C/D ring junction. Compounds >2–6 and >11 showed moderate to potent cytotoxicity with EC50 values ranging from 0.3 to 3 μM against KB and KB-VIN human cancer cell lines. Compounds >6, >10, >11, >14–>16, >18, and >21 exhibited anti-inflammatory NO-production inhibition activity with IC50 values of less than 5 μM, which was more potent than the nonspecific NOS inhibitor N^ω-nitro-L-arginine methyl ester (L-NAME).