SNPs in the Lysyl Oxidase-like Protein 4 (LOXL4) and Complement Component 3 (C3) genes are Associated with Increased Risk for Endometriosis and Endometriosis-Associated Infertility

摘要

This study was conducted to assess genetic associations to endometriosis in a Puerto Rican population. Significant differences in allelic frequencies and genotype distribution of genetic variants in LOXL4 and C3 were documented in patients with endometriosis-associated infertility vs controls, and in patients with endometriosis vs controls, respectively, and in women having the risk genotype at both SNPs, the estimated risk for endometriosis nearly doubled.