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Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA

机译：精氧化酶介导与幽门螺杆菌幽门螺杆菌相关的胃癌风险

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BACKGROUND & AIMSHelicobacter pylori-induced gastric carcinogenesis has been linked to the microbial oncoprotein CagA. Spermine oxidase (SMO) metabolizes the polyamine spermine into spermidine and generates H2O2 that causes apoptosis and DNA damage. We determined if pathogenic effects of CagA are attributable to SMO.

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期刊名称 other
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Rupesh Chaturvedi; Mohammad Asim; Judith Romero-Gallo; Daniel P. Barry; Svea Hoge; Thibaut de Sablet; Alberto G. Delgado; Lydia E. Wroblewski; M. Blanca Piazuelo; Fang Yan; Dawn A. Israel; Robert A. Casero Jr.; Pelayo Correa; Alain P. Gobert; D. Brent Polk; Richard M. Peek Jr.; Keith T. Wilson;
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年(卷),期 -1(141),5
年度 -1
页码 e2
总页数 23
原文格式 PDF
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polyamines epithelial cells DNA damage;

机译：多胺;上皮细胞;DNA损伤;

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专利

1. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. [J] . Chaturvedi R, Asim M, Romero Gallo J, Gastroenterology . 2011,第5期

机译：精胺氧化酶介导与幽门螺杆菌CagA相关的胃癌风险。
2. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk [J] . Rupesh Chaturvedi, Thibaut de Sablet, Richard M. Peek Jr., Gut microbes. . 2012,第1期

机译：精胺氧化酶，一种多胺分解代谢酶，将幽门螺杆菌CagA与胃癌风险联系起来
3. The Gastric Mucosa from Patients Infected with CagA plus or VacA plus Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H-pylori [J] . Li Hongqian, Zhou Yunfeng, Zheng Yufeng, Digestive Diseases and Sciences . 2016,第8期

机译：来自未感染或未感染CagA- / VacA-H-幽门螺杆菌的CagA plus或VacA加幽门螺杆菌感染患者的胃粘膜具有较低的双重氧化酶2表达水平
4. Detection and application of CagA sequence markers for assessing risk factor of gastric cancer caused by Helicobacter pylori [C] . 2010 IEEE International Conference on Bioinformatics and Biomedicine . 2010

机译：CagA序列标记在幽门螺杆菌引起胃癌危险因素评估中的应用
5. Helicobacter pylori stimulates gastric cancer cell motility through a combination of CagA-dependent and CagA-independent signaling [D] . Snider, Jared Lee 2008

机译：幽门螺杆菌通过依赖于CagA和独立于CagA的信号传导刺激胃癌细胞的运动
6. Spermine oxidase a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk [O] . Rupesh Chaturvedi, Thibaut de Sablet, Richard M. Peek Jr., 2012

机译：精胺氧化酶一种多胺分解代谢酶将幽门螺杆菌CagA与胃癌风险联系起来
7. Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA [O] . Rupesh Chaturvedi, Mohammad Asim, Judith Romero–Gallo, 2011

机译：精氧化酶介导与幽门螺杆菌幽门螺杆菌相关的胃癌风险

Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA

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