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Reduced Heterogeneous Expression Of Cx43 Results In Decreased Nav1.5 Expression And Reduced Sodium Current Which Accounts For Arrhythmia Vulnerability In Conditional Cx43 Knockout Mice

机译：降低CX43的异质表达导致NAV1.5表达减少和降低的钠流其鉴于条件CX43敲除小鼠的心律失常脆弱性

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BackgroundReduced Connexin43 (Cx43), sodium channel (Nav1.5) expression and increased collagen expression (fibrosis) are important determinants of impulse conduction in the heart.

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期刊名称 other
作者
John A. Jansen; Maartje Noorman; Hassan Musa; Mèra Stein; Sanne de Jong; Roel van der Nagel; Thomas J. Hund; Peter J. Mohler; Marc A. Vos; Toon A. van Veen; Jacques M. de Bakker; Mario Delmar; Harold V. van Rijen;
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年(卷),期 -1(9),4
年度 -1
页码 600–607
总页数 16
原文格式 PDF
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Cx43 Nav1.5 heterogeneity sodium current arrhythmia;

机译：Cx43;Nav1.5;异质性;钠电流;心律不齐;
入库时间 2022-08-21 11:25:37

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专利

1. Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice [J] . JansenJ.A., NoormanM., MusaH., Heart rhythm: the official journal of the Heart Rhythm Society . 2012,第4期

机译：Cx43异源表达的降低导致Nav1.5表达降低和钠电流降低，这是条件性Cx43基因敲除小鼠心律失常的原因
2. In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms. [J] . Bierhuizen MF, Boulaksil M, van-Stuijvenberg L, Journal of Molecular and Cellular Cardiology . 2008,第3期

机译：在钙调磷酸酶诱导的心肌肥大中，Nav1.5，Cx40和Cx43的表达通过不同的机制降低。
3. ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation. [J] . McLachlan E, Plante I, Shao Q, Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research . 2008,第6期

机译：ODDD连接的Cx43突变体减少成骨细胞中内源性Cx43的表达和功能，并抑制晚期分化。
4. Dietary polyunsaturated fatty acids reduce expression of colonic inflammatory genes in interleukin-10 knockout mice [C] . B. Knock, M.P.G. Barnett, W.C. McNabb, International Symposium on Energy and Protein Metabolism and Nutrition . 2007

机译：饮食多不饱和脂肪酸减少白细胞介素-10敲除小鼠中结肠癌炎症基因的表达
5. Decreased expression of prohormone convertase I and II contributes to adult onset obesity in Nhlh2 knockout mice. [D] . Jing, Enxuan. 2003

机译：原激素转化酶I和II的表达降低有助于Nhlh2基因敲除小鼠的成年肥胖。
6. Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions [O] . Xiao-Hong Wei, Shan-Dong Yu, Lu Ren, -1

机译：抑制晚期钠电流可通过减少CaMK-II的磷酸化和钠通道的表达来抑制钙相关的室性心律失常
7. Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice [O] . Jansen, John A., Noorman, Maartje, Musa, Hassan, 2012

机译：Cx43异源表达的降低导致Nav1.5表达降低和钠电流降低，这是有条件Cx43基因敲除小鼠心律失常的原因

Reduced Heterogeneous Expression Of Cx43 Results In Decreased Nav1.5 Expression And Reduced Sodium Current Which Accounts For Arrhythmia Vulnerability In Conditional Cx43 Knockout Mice

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