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Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity Left Ventricular Function and Perfusion in Chronic Ischemic Heart Failure: The FOCUS-CCTRN Trial

机译：自体骨髓单核细胞颅内膜递送对慢性缺血性心力衰竭的功能能力左心室功能和灌注的影响：焦点 - 中央电池试验

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ContextPrevious studies utilizing autologous bone marrow mononuclear cells (BMCs) in patients with ischemic cardiomyopathy have demonstrated safety and suggested efficacy. The FOCUS protocol was designed to assess efficacy of a larger cell dose in an adequately well-powered phase II study.

机译：利用缺血性心肌病患者的自体骨髓单核细胞（BMC）的ContextPrevious的研究表明了安全性和建议的疗效。焦点协议旨在评估较大的细胞剂量在充分良好的良好良好的阶段研究中的疗效。

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期刊名称 other
作者
Emerson C. Perin; James T. Willerson; Carl J. Pepine; Timothy D. Henry; Stephen G. Ellis; David X.M. Zhao; Guilherme V. Silva; Dejian Lai; James D. Thomas; Marvin W. Kronenberg; A. Daniel Martin; R. David Anderson; Jay H. Traverse; Marc S. Penn; Saif Anwaruddin; Antonis K. Hatzopoulos; Adrian P. Gee; Doris A. Taylor; Christopher R. Cogle; Deirdre Smith; Lynette Westbrook; James Chen; Eileen Handberg; Rachel E. Olson; Carrie Geither; Sherry Bowman; Judy Francescon; Sarah Baraniuk; Linda B. Piller; Lara M. Simpson; Catalin Loghin; David Aguilar; Sara Richman; Claudia Zierold; Judy Bettencourt; Shelly L. Sayre; Rachel W. Vojvodic; Sonia I. Skarlatos; David J. Gordon; Ray F. Ebert; Minjung Kwak; Lemuel A. Moyé; Robert D. Simari;
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年(卷),期 -1(307),16
年度 -1
页码 1717–1726
总页数 19
原文格式 PDF
正文语种
中图分类
关键词
Chronic CAD Ischemic Heart Failure Chronic Angina bone marrow mononuclear cells cardiac performance;

机译：慢性CAD;缺血性心力衰竭;慢性心绞痛;骨髓单个核细胞;心脏表现;

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1. Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure: The FOCUS-CCTRN Trial (vol 307, pg 1717, 2012) [J] . Perin E. C., Willerson J. T., Pepine C. J. JAMA: the Journal of the American Medical Association . 2015,第1期

机译：心内膜递送自体骨髓单个核细胞对慢性心力衰竭患者功能能力，左心室功能和灌注的影响：FOCUS-CCTRN试验（第307卷，第1717页，2012年）
2. Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: The FOCUS-CCTRN trial [J] . PerinE.C., WillersonJ.T., PepineC.J., JAMA: the Journal of the American Medical Association . 2012,第16期

机译：心内膜递送自体骨髓单个核细胞对慢性心力衰竭患者功能能力，左心室功能和灌注的影响：FOCUS-CCTRN试验
3. Rationale and design of the Transendocardial Injection of Autologous Human Cells (bone marrow or mesenchymal) in Chronic Ischemic Left Ventricular Dysfunction and Heart Failure Secondary to Myocardial Infarction (TAC-HFT) trial: A randomized, double-blind, placebo-controlled study of safety and efficacy. [J] . Trachtenberg B, Velazquez DL, Williams AR, The American heart journal . 2011,第3期

机译：经心内膜注射自体人类细胞（骨髓或间充质）治疗继发于心肌梗塞的慢性缺血性左心室功能不全和心力衰竭（TAC-HFT）试验的原理和设计：一项随机，双盲，安慰剂对照的安全性研究和功效。
4. Regeneration of Human Infarcted Heart Muscle by Intracoronary Autologous Mononuclear Bone Marrow Cells in Chronic Coronary Artery Disease [C] . M. Kostering, M. Brehm, T. ZeusT. Bartsch, Nordrhein-Westfa?lische Akademie der Wissenschaften . 2005

机译：核内自体单核骨骨髓细胞在慢性冠状动脉疾病中的再生治疗人梗死的心肌
5. Wnt11-preprogrammed bone marrow mononuclear cells undergo cardiomyogenic differentiation and improve cardiac function following transplantation in the post-infarcted murine heart. [D] . Flaherty, Michael Patrick. 2009

机译：Wnt11预编程的骨髓单核细胞在梗死后的小鼠心脏中移植后经历心肌分化并改善心脏功能。
6. Rationale and Design for the Intramyocardial Injection of Autologous Bone Marrow Mononuclear Cells for Patients with Chronic Ischemic Heart Disease and Left Ventricular Dysfunction Trial (FOCUS) [O] . James T. Willerson, Emerson C. Perin, Stephen G. Ellis, -1

机译：原理和设计为自体骨髓单个核细胞对慢性缺血性心脏病和左室功能不全试验患者的心肌内注射（FOCUs）
7. Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure [O] . Emerson C. Perin, James T. Willerson, Carl J. Pepine, 2012

机译：自体内骨髓单核细胞颅内膜递送对慢性心力衰竭的功能容量，左心室功能和灌注的影响

Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity Left Ventricular Function and Perfusion in Chronic Ischemic Heart Failure: The FOCUS-CCTRN Trial

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