Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II

机译：拉帕酚通过靶向DNA拓扑异构酶I和拓扑异构酶II在体外和体内对大鼠C6胶质瘤的抑制作用

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BackgroundLapachol is a natural naphthoquinone compound that possesses extensive biological activities. The aim of this study is to investigate the inhibitory effects of lapachol on rat C6 glioma both in vitro and in vivo, as well as the potential mechanisms.

机译：背景拉帕酚是具有广泛生物活性的天然萘醌化合物。这项研究的目的是研究拉帕酚在体外和体内对大鼠C6胶质瘤的抑制作用以及潜在的机制。

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期刊名称 Journal of Experimental Clinical Cancer Research : CR
作者
Huanli Xu; Qunying Chen; Hong Wang; Pingxiang Xu; Ru Yuan; Xiaorong Li; Lu Bai; Ming Xue;
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作者单位

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年(卷),期 2016(35),-1
年度 2016
页码 178
总页数 10
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Lapachol C6 glioma Topoisomerase I Topoisomerase II;

机译：Lapachol;C6胶质瘤;拓扑异构酶I;拓扑异构酶II;

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专利

1. Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II [J] . Huanli Xu, Qunying Chen, Hong Wang, Journal of experimental & clinical cancer research : . 2016,第1期

机译：拉帕酚通过靶向DNA拓扑异构酶I和拓扑异构酶II在体外和体内对大鼠C6胶质瘤的抑制作用
2. Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru_2Cl(Ibp)_4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo [J] . Marcel Benadiba, Iguatin?de M. Costa, Rodrigo L. S. R. Santos, Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry . 2014,第6期

机译：钌-布洛芬化合物[Ru_2Cl（Ibp）_4]在人脑胶质瘤细胞中和在大鼠C6原位神经胶质瘤中的生长抑制作用
3. Anticancer activity of dihydropyrazolo[1,5‐ c c ]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II [J] . Kaur Gagandeep, Cholia Ravi P., Joshi Gaurav, Archiv der Pharmazie . 2018,第6期

机译：二氢吡唑[1,5-C]喹唑啉对大鼠C6胶质瘤细胞的抗癌活性通过抑制Topoisomerase II
4. Mechanism of enhancement effect of carbon-beam irradiation and topoisomerase II inhibitor on two cell lines with different radiosensitivities and different p53 status in vitro [C] . Takahashi T, Yoshida Y, Musha A, Annual Meeting of the European Radiation Research Society . 2009

机译：碳光束辐射和拓扑异构酶II抑制剂在两种细胞系中具有不同辐射敏感度的细胞系和不同P53状态的机制
5. Mechanistic studies of eukaryotic type II DNA topoisomerase and its interaction with topo II-targeting drugs. [D] . Hu, Tao. 2001

机译：真核II型DNA拓扑异构酶及其与topo II靶向药物相互作用的机理研究。
6. Topoisomerase II and other DNA-delay and DNA-arrest mutations impair bacteriophage T4 DNA packaging in vivo and in vitro. [O] . A Zachary, L W Black 1986

机译：拓扑异构酶II和其他DNA延迟和DNA逮捕突变在体内和体外损害噬菌体T4 DNA包装。
7. Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II [O] . 2016

机译：拉帕酚通过靶向DNA拓扑异构酶I和拓扑异构酶II在体外和体内对大鼠C6胶质瘤的抑制作用
8. Genotoxicity of Inhibitors of DNA Topoisomerases I (Camptothecin) and II (m-AMSA)In vivo and In vitro [R] . Backer, L. C., Allen, J. W., Harrington-Brock, K., 1990

机译：DNa拓扑异构酶I（喜树碱）和II（m-amsa）抑制剂在体内和体外的遗传毒性

Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II

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