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Measurement of refractive index by nanoparticle tracking analysis reveals heterogeneity in extracellular vesicles

机译:通过纳米粒子跟踪分析的折射率测量揭示了细胞外囊泡的异质性

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摘要

IntroductionOptical techniques are routinely used to size and count extracellular vesicles (EV). For comparison of data from different methods and laboratories, suitable calibrators are essential. A suitable calibrator must have a refractive index (RI) as close to that of EV as possible but the RI of EV is currently unknown. To measure EV, RI requires accurate knowledge of size and light scattering. These are difficult to measure as most EVs cannot be resolved by light microscopy and their diameter is smaller than the wavelength of visible light. However, nanoparticle tracking analysis (NTA) provides both size and relative light scattering intensity (rLSI) values. We therefore sought to determine whether it was possible to use NTA to measure the RI of individual EVs.
机译:简介光学技术通常用于对细胞外囊泡(EV)进行大小和计数。为了比较不同方法和实验室的数据,必须使用合适的校准器。合适的校准器必须具有尽可能接近EV的折射率(RI),但是EV的RI目前未知。为了测量EV,RI需要准确了解尺寸和光散射。这些很难测量,因为大多数电动汽车无法通过光学显微镜分辨,并且它们的直径小于可见光的波长。但是,纳米粒子跟踪分析(NTA)提供大小和相对光散射强度(rLSI)值。因此,我们试图确定是否有可能使用NTA来测量单个电动汽车的RI。

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