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MicroRNA-15a and MicroRNA-16 Impair Human Circulating Proangiogenic Cell Functions and Are Increased in the Proangiogenic Cells and Serum of Patients With Critical Limb Ischemia

机译：MicroRNA-15A和MicroRNA-16损害人循环的雌激细胞功能并且在临时肢体缺血患者的致胰腺细胞和血清中增加

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RationaleCirculating proangiogenic cells (PACs) support postischemic neovascularization. Cardiovascular disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that are not fully known. We hypothesize a role for microRNAs (miRs). Circulating miRs are currently investigated as potential diagnostic and prognostic biomarkers.

机译：基本原理循环促血管生成细胞（PAC）支持缺血后新血管形成。心血管疾病和糖尿病通过尚不完全清楚的分子机制破坏PAC的再生能力。我们假设microRNA（miRs）的作用。目前正在研究循环miRs作为潜在的诊断和预后生物标志物。

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期刊名称 other
作者
Gaia Spinetti; Orazio Fortunato; Andrea Caporali; Saran Shantikumar; Micol Marchetti; Marco Meloni; Betty Descamps; Ilaria Floris; Elena Sangalli; Rosa Vono; Ezio Faglia; Claudia Specchia; Gianfranco Pintus; Paolo Madeddu; Costanza Emanueli;
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年(卷),期 -1(112),2
年度 -1
页码 335–346
总页数 22
原文格式 PDF
正文语种
中图分类
关键词
angiogenesis diabetes mellitus ischemia microRNAs microRNA-15a microRNA-16 proangiogenic cells;

机译：血管生成;糖尿病;局部缺血;microRNA;microRNA-15a;microRNA-16;促血管生成细胞;

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1. MicroRNA-15a and MicroRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia [J] . SpinettiG., FortunatoO., CaporaliA., Circulation research: a journal of the American Heart Association . 2013,第2期

机译：MicroRNA-15a和MicroRNA-16损害人类循环性促血管生成细胞功能，并在严重肢体缺血患者的促血管生成细胞和血清中增加
2. Pretreatment of Diabetic Adipose-derived Stem Cells with mitoTEMPO Reverses their Defective Proangiogenic Function in Diabetic Mice with Critical Limb Ischemia [J] . Lian Kun, Wang Qin, Zhao Shuai, Cell transplantation . 2019,第12期

机译：具有Mitotempo的糖尿病脂肪衍生的干细胞的预处理反转其患糖尿病小鼠的缺陷致肢体缺血功能
3. Glyoxalase‐1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose‐Derived Stem Cells in Streptozotocin‐Induced Diabetic Mice Model of Critical Limb Ischemia [J] . Zhiyou Peng, Xinrui Yang, Jinbao Qin, Stem cells translational medicine. . 2017,第1期

机译：乙二醛-1的过表达逆转了链脲佐菌素诱发的下肢缺血性糖尿病小鼠模型中糖尿病脂肪干细胞的促血管生成功能缺陷。
4. A Prosurvival and Proangiogenic Stem Cell Delivery System to Promote Ischemic Limb Regeneration [C] . Yanyi Xu, Minghuan Fu, Zhihong Li, World biomaterials congress . 2016

机译：Prosurvivin和proangiogenic干细胞传递系统，以促进缺血性肢体再生。
5. Enhanced Proangiogenic Activity of Endothelial Cells in Response to Polyglutamate Domain-Modified QK Peptides Delivered on Bone Grafting Materials [D] . Pensa, Nicholas Weldon. 2019

机译：响应于骨嫁接材料递送的聚谷氨酰胺结构域改性QK肽增强了内皮细胞的常致细胞活性
6. Glyoxalase‐1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose‐Derived Stem Cells in Streptozotocin‐Induced Diabetic Mice Model of Critical Limb Ischemia [O] . Zhiyou Peng, Xinrui Yang, Jinbao Qin, 2017

机译：乙二醛-1的过表达逆转了由链脲佐菌素诱导的严重肢体缺血的糖尿病小鼠模型中糖尿病脂肪衍生干细胞的促血管生成功能缺陷。
7. MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia [O] . Spinetti, Gaia, Fortunato, Orazio, Caporali, Andrea, 2013

机译：microRNa-15a和microRNa-16损害人体循环促血管生成细胞功能，并且在患有严重肢体缺血的患者的促血管生成细胞和血清中增加

MicroRNA-15a and MicroRNA-16 Impair Human Circulating Proangiogenic Cell Functions and Are Increased in the Proangiogenic Cells and Serum of Patients With Critical Limb Ischemia

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