2-Cinnamamido 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides: Synthesis antiproliferative activity and mechanism of action

摘要

Several new benzamides >4a–q were synthesized by stirring in pyridine the acid chlorides >3a–q with the appropriate anthranilamide derivatives >2a–g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).