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Designing a multipurpose technology for acceptability and adherence

机译:设计一种用于接受和遵守的多功能技术

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摘要

Multipurpose Prevention Technologies (MPTs) are new tools aimed at reducing or preventing multiple and overlapping sexual and reproductive health risks faced by women and couples around the globe. While MPTs could prove more acceptable and easier to adhere to than single-purpose prevention products, continuing high rates of HIV and unintended pregnancy remind us that these new products will need to be efficacious, acceptable and effectively used to achieve a public health impact. In this paper, we describe how a range of research methods can be applied during the pre-clinical phase of product development to inform decisions related to formulation and vehicle or product delivery mechanisms, and consider how choices in product-related characteristics may influence future demand for, delivery and use of future products. We draw on examples from the development of new single-purpose HIV and contraceptive products and then extend our discussion to the development of MPTs, including vaginal rings and injections. This article is based on a presentation at the “Product Development Workshop 2013: HIV and Multipurpose Prevention Technologies,” held in Arlington, Virginia on February 21-22, 2013. It forms part of a special supplement to Antiviral Research.
机译:多用途预防技术(MPT)是旨在减少或预防全球妇女和夫妇面临的多重和重叠的性健康和生殖健康风险的新工具。虽然MPT可能比单一目的的预防产品更容易被接受,但继续存在的高艾滋病毒感染率和意外怀孕提醒我们,这些新产品将需要有效,可接受和有效地用于实现对公共健康的影响。在本文中,我们描述了如何在产品开发的临床前阶段应用一系列研究方法,以指导与配方和车辆或产品交付机制有关的决策,并考虑与产品相关的特征的选择如何影响未来需求用于,交付和使用未来产品。我们从新的单一用途HIV和避孕产品的开发中汲取了一些例子,然后将讨论扩展到MPT的开发,包括阴道环和注射剂。本文基于2013年2月21日至22日在弗吉尼亚州阿灵顿市举行的“ 2013年产品开发研讨会:HIV和多用途预防技术”上的演讲。它构成了抗病毒研究特别补充的一部分。

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