Compacts containing selected bioadhesive polymers, fillers, and binders were investigated for their potential as a bioadhesive gastroretentive delivery system to deliver water soluble and water insoluble compounds in the stomach. Compacts with 90:10, 75:25, and 60:40 of polyvinylpyrrolidone (PVP) and polyethylene oxide (PEO) were evaluated for swelling, dissolution, bioadhesion, and in vitro gastric retention. Compacts containing higher PEO showed higher swelling (111.13%) and bioadhesion (0.62 ± 0.03 N/cm2), and retained their integrity and adherence onto gastric mucosa for about 9 h under in vitro conditions. In vivo gastroretentive property of compacts were evaluated in Yorkshire cross swines. Compacts containing 58% PVP, 40% PEO and 2% of water soluble or water insoluble marker compounds showed gastroadhesive and retentive properties in vivo. It is concluded that PEO in combination with PVP yields a non disintegrating type bioadhesive dosage form which is suitable for gastroretentive applications.
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机译：研究了包含选定生物粘附性聚合物，填充剂和粘合剂的压粉作为生物粘附性胃滞留递送系统在胃中递送水溶性和水不溶性化合物的潜力。评价具有90：10、75：25和60:40的聚乙烯吡咯烷酮（PVP）和聚环氧乙烷（PEO）的压块的肿胀，溶解，生物粘附和体外胃gastric留。含较高PEO的粉饼在体外条件下表现出较高的溶胀（111.13％）和生物粘附性（0.62±0.03 N / cm 2 ），并保持其完整性和对胃粘膜的粘附力约9小时。在约克郡杂交猪中评估了压粉的体内胃滞留性质。包含58％PVP，40％PEO和2％水溶性或水不溶性标记化合物的压粉在体内显示出气密性和保持性。结论是，PEO与PVP结合可产生非崩解型生物粘附剂型，适用于胃滞性应用。
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