Compartmental models for apical efflux by P-glycoprotein. Part 2. A theoretical study on transporter kinetic parameters

摘要

PurposeThe impact of efflux transporters in intracellular concentrations of a drug can be predicted with modeling techniques. In Part 1, several compartmental models were developed and evaluated. The goal of Part 2 was to apply these models to the characterization and interpretation of saturation kinetic data.