Co-transplantation with Myeloid-Derived Suppressor Cells Protects Cell Transplants: A Crucial Role of Inducible Nitric Oxide Synthase

摘要

BackgroundIslet transplantation is an alternative to pancreas transplantation to cure type 1 diabetes, but both require chronic immunosuppression, which is often accompanied by deleterious side effects. The purpose of this study was to explore prolongation of islet allograft survival by co-transplantation with myeloid-derived suppressor cells (MDSCs) without requirement of immunosuppression, and determine the role of inducible nitric oxide synthase (iNOS) produced by MDSCs in immune regulation.