Periostin is Upregulated in Coronary Arteriopathy in Kawasaki Disease and is a Potential Diagnostic Biomarker

摘要

Periostin was upregulated 11-fold in acute and chronic KD coronary arteries compared with controls (p=0.003). KD patients had significantly elevated serum periostin values compared with febrile controls (p=0.0086). There was no relationship between serum periostin values and age, gender, or acute phase reactants; there was a relationship between serum periostin and maximal coronary artery Z scores that did not reach significance (p=0.08). Periostin may prove to be useful as a component of a future diagnostic biomarker panel for KD.