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Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss

机译：圆形窗位中的控释地塞米松植入物用于特发性特发性感觉神经性听力损失的抢救治疗

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摘要

ObjectiveTo evaluate the feasibility and hearing outcome of a biocompatible degradable dexamethasone releasing implant for continuous drug delivery to the round window membrane in patients with idiopathic sudden sensorineural hearing loss (ISSHL) and insufficient recovery after systemic high dose glucocorticoid therapy.

机译：目的评估生物相容性可降解地塞米松释放植入物在全身性大剂量糖皮质激素治疗后特发性突然感觉神经性听力损失（ISSHL）和康复不足的患者中连续给药至圆窗膜的可行性和听力结果。

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期刊名称 other
作者
Stefan K. Plontke; Alexander Glien; Torsten Rahne; Karsten Mäder; Alec N. Salt;
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年(卷),期 -1(35),7
年度 -1
页码 1168–1171
总页数 10
原文格式 PDF
正文语种
中图分类
关键词
controlled release glucocorticosteroids steroids dexamethasone sudden hearing loss local drug delivery round window cochlea rescue salvage treatment human;

机译：控释;糖皮质激素;类固醇;地塞米松;突然听力下降;局部药物输送;圆窗;耳蜗;抢救;抢救治疗;人类;

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1. Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss. [J] . Stefan K Plontke, Alexander Glien, Torsten Rahne, Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology . 2014,第7期

机译：圆形窗位中的控释地塞米松植入物用于特发性突然感觉神经性听力损失的抢救治疗。
2. In reference to Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy (Laryngoscope 119:359-369, 2009). [J] . Nakashima T, Teranishi M, Yoshida T The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. . 2009,第12期

机译：参照随机，双盲，安慰剂对照试验，探讨通过圆窗导管递送持续鼓膜内地塞米松治疗系统治疗失败后重度至重度特发性特发性感音神经性听力损失的安全性和有效性（喉镜119：359-369，2009）。
3. Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemi [J] . Plontke SK, Lowenheim H, Mertens J, The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. . 2009,第2期

机译：随机，双盲，安慰剂对照试验，关于通过圆窗导管递送持续鼓膜内地塞米松治疗系统性衰竭后重度至重度特发性特发性感音神经性听力损失的安全性和有效性
4. Intravenous injection of human umbilical cord-derived mesenchymal stem cells for the treatment of sudden sensorineural hearing loss: a case report [C] . Hua Liu, Zhiping Qu, Shanhui Sun, International Conference on Medical Engineering and Bioinformatics . 2015

机译：静脉内注射人脐带源性间充质干细胞，用于治疗突如其来的感官听力损失：案例报告
5. Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss [D] . Koide Yusuke, 小出悠介 2019

机译：解偶联蛋白2基因Ala55val多态性与突然的感音神经性听力丧失之间的关联。
6. Idiopathic sudden sensorineural hearing loss: Effectiveness of salvage treatment with low-dose intratympanic dexamethasone [O] . Pedro Salvador, Francisco Moreira da Silva, Rui Fonseca 2021

机译：特发性突如其来的感觉损失：用低剂量尿酸尿布塞米松治疗救人治疗的有效性
7. Controlled Release Dexamethasone Implants in the Round Window Niche for Salvage Treatment of Idiopathic Sudden Sensorineural Hearing Loss [O] . Stefan K. Plontke, Alexander Glien, Torsten Rahne, 2014

机译：控制释放地塞米松植入圆形窗口的植入物，用于治疗特发性突如其来的感觉听力损失

Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss

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