Extending Semi-Automatic Ventilation Defect Analysis for Hyperpolarized 129Xe Ventilation MRI

摘要

Rationale and ObjectivesClinical deployment of hyperpolarized (HP) ¹²⁹Xe MRI requires accurate quantification and visualization of the ventilation defect percentage (VDP). Here, we improve the robustness of our previous semi-automated analysis method to reduce operator dependence, correct for B1 inhomogeneity and vascular structures, and extend the analysis to display multiple intensity clusters.