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Angiotensin II increases the expression of (pro)renin receptor during low salt conditions in rat renal inner medullary collecting ducts

机译:血管紧张素II在低盐条件下增加大鼠肾内髓质收集管中(原)肾素受体的表达

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摘要

IntroductionEvidence indicates that chronic angiotensin II (AngII) infusion increases (pro)renin receptor ((P)RR) expression in rat renal inner medullary collecting ducts (IMCDs) cells. Recently, it was shown that renal (P)RR expression is augmented during low salt (LS) diet. However, the role of AngII in mediating the stimulation of (P)RR during LS conditions is unknown. We hypothesized that AngII mediates the increased expression of (P)RR during low salt conditions in IMCDs.
机译:引言有证据表明,慢性血管紧张素II(AngII)输注会增加大鼠肾脏内髓样收集管(IMCDs)细胞中的(pro)肾素受体((P)RR)表达。最近,研究表明在低盐(LS)饮食期间肾脏(P)RR表达增加。然而,尚不清楚AngII在LS条件下介导(P)RR刺激的作用。我们假设AngII介导IMCD中低盐条件下(P)RR的表达增加。

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