Transcription factor Brn-3b overexpression enhances neurite outgrowth in PC12 cells under condition of hypoxia

摘要

BackgroundTranscription factor Brn-3b plays a key role in retinal ganglion cell differentiation, survival and axon outgrowth during development. However, the precise role of Brn-3b in the normal adult retina as well as during neurodegeneration is unclear. In the current study, the effect of overexpression of Brn-3b was assessed in vitro, in PC12 cells under conditions of normoxia and hypoxia.