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Metabolic and Kidney Disorders Correlate with High Atazanavir Concentrations in HIV-Infected Patients: Is It Time to Revise Atazanavir Dosages?

机译：代谢和肾脏疾病与艾滋病毒感染患者的高阿扎那韦浓度有关：是时候修改阿扎那韦剂量吗？

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IntroductionRitonavir-boosted atazanavir (ATV/r) is a relatively well tolerated antiretroviral drug. However, side effects including hyperbilirubinemia, dyslipidemia, nephrolithiasis and cholelithiasis have been reported in the medium and long term. Unboosted ATV may be selected for some patients because it has fewer gastrointestinal adverse effects, less hyperbilirubinemia and less impact on lipid profiles.

机译：简介利托那韦增强的阿扎那韦（ATV / r）是一种相对耐受良好的抗逆转录病毒药物。然而，在中长期中已经报道了包括高胆红素血症，血脂异常，肾结石和胆石症的副作用。对于某些患者，可以选择不加药的ATV，因为它具有较少的胃肠道不良反应，较少的高胆红素血症和对脂质分布的影响。

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Cristina Gervasoni; Paola Meraviglia; Davide Minisci; Laurenzia Ferraris; Agostino Riva; Simona Landonio; Valeria Cozzi; Nitin Charbe; Lara Molinari; Giuliano Rizzardini; Emilio Clementi; Massimo Galli; Dario Cattaneo;
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年(卷),期 -1(10),4
年度 -1
页码 e0123670
总页数 12
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1. Effect of nevirapine on the steady-state trough concentrations of atazanavir in HIV-infected patients receiving atazanavir/ritonavir. [J] . Molto J, Deig E, Valle Therapeutic Drug Monitoring . 2010,第1期

机译：奈韦拉平对接受Atazanavir / ritonavir感染HIV的患者中atazanavir稳态谷浓度的影响。
2. Safety and feasibility of treatment simplification to atazanavir/ritonavir + lamivudine in HIV-infected patients on stable treatment with two nucleos(t)ide reverse transcriptase inhibitors + atazanavir/ritonavir with virological suppression (Atazanavir and Lamivudine for treatment Simplification, AtLaS pilot study). [J] . Simona Di Giambenedetto, Massimiliano Fabbiani, Manuela Colafigli, The Journal of Antimicrobial Chemotherapy . 2013,第6期

机译：使用两种具有病毒学抑制作用的核苷酸逆转录酶抑制剂+阿扎那韦/利托那韦稳定治疗的HIV感染患者中，简化阿扎那韦/利托那韦+拉米夫定治疗的安全性和可行性（阿扎那韦和拉米夫定用于简化治疗，AtLaS初步研究）。
3. Safety and feasibility of treatment simplification to atazanavir/ritonavir + lamivudine in HIV-infected patients on stable treatment with two nucleos(t)ide reverse transcriptase inhibitors + atazanavir/ritonavir with virological suppression (Atazanavir and Lamivudine for treatment Simplification, AtLaS pilot study). [J] . Simona Di Giambenedetto, Massimiliano Fabbiani, Manuela Colafigli, The Journal of Antimicrobial Chemotherapy . 2013,第6期

机译：治疗的安全性和可行性对Atazanavir / Ritonavir + Lamivudine在艾滋病毒（T）IDE逆转录酶抑制剂+ Atazanavir / Ritonavir中的稳定治疗，具有病毒学抑制（Atazanavir和Lamivinde，用于治疗简化，地图集试验研究）。
4. Prediction of Cyclosporine Blood Concentration and Dosage in Kidney Transplantation Patients: Comparison of Multiple Linear Regression and Neural Networks [C] . Shan Li, Yao Chen, Qin Yan ICCEE 2010;International conference on computer and electrical engineering . 2010

机译：肾移植患者环孢素血药浓度和剂量的预测：多重线性回归和神经网络的比较
5. Demographic and Clinical Correlates of Palliative Care in HIV-Infected and Uninfected Patients Hospitalized with Heart Failure. [D] . Feder, Shelli L. 2017

机译：患有心力衰竭住院的HIV感染和未感染患者的姑息治疗的人口统计学和临床相关性。
6. Influence of Alpha-1 Glycoprotein Acid Concentrations and Variants on Atazanavir Pharmacokinetics in HIV-Infected Patients Included in the ANRS 107 Trial [O] . A. Barrail-Tran, F. Mentré, C. Cosson, 2010

机译：ANRS 107试验中包括Alpha-1糖蛋白酸浓度和变异对Atazanavir药代动力学在HIV感染患者中的影响
7. Metabolic and kidney disorders correlate with high atazanavir concentrations in HIV-infected patients: is it time to revise atazanavir dosages? [O] . Cristina Gervasoni, Paola Meraviglia, Davide Minisci, 2015

机译：代谢和肾脏疾病与HIV感染患者的高阿扎那韦浓度相关：是时候修改阿扎那韦剂量了吗？

Metabolic and Kidney Disorders Correlate with High Atazanavir Concentrations in HIV-Infected Patients: Is It Time to Revise Atazanavir Dosages?

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