A fluorescent bisboronic acid compound that selectively labels cells expressing oligosaccharide Lewis X

摘要

Two fluorescent diboronic acid compounds (>6a and >6b) with a dipeptide linker were synthesized as potential sensors for cell surface saccharide Lewis X (Le^X). Compound >6a with a dipeptide (H-Asp-Ala-) as the linker was found to selectively label CHOFUT4 cells, which express Le^x, at micromolar concentrations, while non-Le^x-expressing control cells were not labeled.