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Human liver-resident CD56bright/CD16neg NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways

机译：人肝驻留CD56bright / CD16neg NK细胞通过CCR5和CXCR6途径参与而保留在肝窦内

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RationaleThe liver-specific natural killer (NK) cell population is critical for local innate immune responses, but the mechanisms that lead to their selective homing and the definition of their functionally relevance remain enigmatic.

机译：基本原理肝脏特异性自然杀伤（NK）细胞群体对于局部先天免疫反应至关重要，但导致其选择性归巢的机制及其功能相关性的定义仍然是个谜。

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期刊名称 other
作者
Kelly Hudspeth; Matteo Donadon; Matteo Cimino; Elena Pontarini; Paolo Tentorio; Max Preti; Michelle Hong; Antonio Bertoletti; Silvio Bicciato; Pietro Invernizzi; Enrico Lugli; Guido Torzilli; M. Eric Gershwin; Domenico Mavilio;
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年(卷),期 -1(66),-1
年度 -1
页码 40–50
总页数 25
原文格式 PDF
正文语种
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关键词
Liver immunology Homing of hepatic NK cells Chemokine Receptors;

机译：肝免疫学;肝NK细胞归巢;趋化因子受体;

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专利

1. Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways [J] . Hudspeth Kelly, Donadon Matteo, Cimino Matteo, Journal of Autoimmunity . 2016,第Null期

机译：人肝驻留CD56（亮）/ CD16（阴性）NK细胞通过CCR5和CXCR6途径参与而保留在肝窦内
2. Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways [J] . Hudspeth Kelly, Donadon Matteo, Cimino Matteo, Journal of Autoimmunity . 2016,第Null期

机译：通过CCR5和CXCR6途径的接合，人肝常规CD56（明亮）/ CD16（NAC）NK细胞保留在肝脏正弦骨内
3. SIVagmSab uses CXCR6 to enter sabaeus african green monkey lymphocytes, suggesting non-CCR5 pathway use is common in natural host infection [J] . Wetzel Katherine S., Yi Yanjie, Elliott Sarah T. C., Journal of medical primatology . 2017,第4期

机译：Sivagmsab使用CXCR6进入Sabaeus非洲绿猴淋巴细胞，表明非CCR5途径在天然宿主感染中常见
4. Musca domestica Larvae Lectin Induced Apoptosis in Human Breast Cancer MCF-7 Cells through ROS-JNK Mediated Caspase Pathway and ROS-Ca2;+ Pathway [C] . Wang Zhuo, Cao Xiao-hong, Hou Li-hua, 5th International Conference on Bioinformatics and Biomedical Engineering . 2011

机译：家蝇幼虫凝集素通过ROS-JNK介导的Caspase途径和ROS-Ca2; +途径诱导人乳腺癌MCF-7细胞凋亡
5. Dual Modulator of the Akt and JNK Pathways Targets mTOR in Human Adenocarcinoma Cells [D] . Curless, Blair P. 2018

机译：Akt和JNK途径的双重调节剂靶向人类腺癌细胞中的mTOR
6. Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids [O] . H. A. McNamara, Y. Cai, M. V. Wagle, -1

机译：LFA-1的上调使肝驻留记忆T细胞巡逻并保留在肝窦中
7. Human liver-resident CD56^bright/CD16^neg NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways [O] . Hudspeth, Kelly, Donadon, Matteo, Cimino, Matteo, 2016

机译：通过CCR5和CXCR6通路的参与，人类肝驻留CD56 ^{/ CD16 ^{neg NK细胞被保留在肝窦内}}

Human liver-resident CD56bright/CD16neg NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways

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