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HIV-1 Drug Resistance and Second-line Treatment in Children Randomized to Switch at Low versus Higher RNA Thresholds

机译：儿童的HIV-1耐药性和二线治疗随机分为低RNA阈值和高RNA阈值

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摘要

BackgroundThe PENPACT-1 trial compared virologic thresholds to determine when to switch to second-line antiretroviral therapy (ART). Using PENPACT-1 data, we aimed to describe HIV-1 drug resistance accumulation on first-line ART by virologic threshold.

机译：背景PENPACT-1试验比较了病毒学阈值，以确定何时改用二线抗逆转录病毒疗法（ART）。我们使用PENPACT-1数据，旨在通过病毒学阈值描述一线抗病毒药物对HIV-1的耐药性积累。

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期刊名称 other
作者
Linda Harrison; Ann Melvin; Susan Fiscus; Yacine Saidi; Eleni Nastouli; Lynda Harper; Alexandra Compagnucci; Abdel Babiker; Ross McKinney; Diana Gibb; Gareth Tudor-Williams;
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年(卷),期 -1(70),1
年度 -1
页码 42–53
总页数 23
原文格式 PDF
正文语种
中图分类
关键词
drug resistance children virologic switch-criteria second-line antiretroviral therapy;

机译：耐药性;儿童;病毒学转换标准;二线抗逆转录病毒疗法;

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专利

1. HIV-1 Drug Resistance and Second-Line Treatment in Children Randomized to Switch at Low Versus Higher RNA Thresholds [J] . Harrison Linda, Melvin Ann, Fiscus Susan, JAIDS: Journal of acquired immune deficiency syndromes . 2015,第1期

机译：儿童对HIV-1的耐药性和二线治疗随机分配至较低的RNA阈值和较高的RNA阈值
2. Switch to second-line versus continued first-line antiretroviral therapy for patients with low-level HIV-1 viremia: An open-label randomized controlled trial in Lesotho [J] . Alain Amstutz, Bienvenu Lengo Nsakala, Fiona Vanobberghen, PLoS Medicine . 2020,第9期

机译：切换到二线与持续的一线抗逆转录病毒治疗，用于低水平的HIV-1病毒血症：莱索托的开放标签随机对照试验
3. An international, multicenter, randomized phase III study of first-line erlotinib followed by second-line cisplatin/gemcitabine versus first-line cisplatin/gemcitabine followed by second-line erlotinib in advanced non-small-cell lung cancer: treatment rationale and protocol dynamics of the TORCH trial. [J] . Gridelli C, Butts C, Ciardiello F, Clinical lung cancer . 2008,第4期

机译：国际，多中心，随机，III期研究对晚期非小细胞肺癌一线埃罗替尼，二线顺铂/吉西他滨与一线顺铂/吉西他滨，二线埃洛替尼进行二线研究：治疗原理和方案动态TORCH审判。
4. An access-transistor-free (0T/1R) non-volatile resistance random access memory (RRAM) using a novel threshold switching, self-rectifying chalcogenide device [C] . Yi-Chou Chen, Chen C.F., Chen C.T., Electron Devices Meeting, 2003. IEDM '03 Technical Digest. IEEE International . 2003

机译：使用新型阈值开关，自整流硫族化物器件的无访问晶体管（0T / 1R）非易失性电阻随机存取存储器（RRAM）
5. Barriers to Switching Patients to Second-Line Antiretroviral Treatment Among Clinicians in Tanzania. [D] . Mgosha, Peter Charles. 2017

机译：坦桑尼亚临床医生中将患者转换为二线抗逆转录病毒治疗的障碍。
6. Switch to second-line versus continued first-line antiretroviral therapy for patients with low-level HIV-1 viremia: An open-label randomized controlled trial in Lesotho [O] . Alain Amstutz, Bienvenu Lengo Nsakala, Fiona Vanobberghen, 2020

机译：切换到二线与持续的一线抗逆转录病毒治疗用于低水平的HIV-1病毒血症：莱索托的开放标签随机对照试验
7. HIV-1 drug resistance and second-line treatment in children randomized to switch at low versus higher RNA thresholds [O] . Harrison, Linda, Melvin, Ann, Fiscus, Susan, 2015

机译：儿童的HIV-1耐药性和二线治疗被随机分配为低RNA阈值和较高RNA阈值

HIV-1 Drug Resistance and Second-line Treatment in Children Randomized to Switch at Low versus Higher RNA Thresholds

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