COMBINATION OF SPECIFIC FRAGMENTS OF DRUG RESISTANCE GENE FOR FOUR KINDS OF SECOND-LINE DRUGS OF MYCOBACTERIUM TUBERCULOSIS AND USE THEREOF

摘要

Provided are a combination of nucleic fragments related to a mycobacterium tuberculosis drug-resistant test of four kinds of second-line drugs, fluoroquinolones, aminoglycosides such as kanamycin and amikacin (amikacin (BBK 8)), and cyclopeptides such as capreomycin for the treatment of tuberculosis and a use thereof. In particular, provided are a combination of mutation nucleic fragment of a promoter of drug-resistance related genes gyrA of fluoroquinolones, drug-resistance related genes rrs and eis of aminoglycosides such as kanamycin and amikacin (amikacin (BBK 8)), and cyclopeptides such as capreomycin, an oligonucleotide probe for the specific detection of mutations, a kit prepared therefrom and a relevant drug-resistance detection method.